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What the human sperm methylome tells us

Overview of attention for article published in Epigenomics, October 2017
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

twitter
7 tweeters

Citations

dimensions_citation
11 Dimensions

Readers on

mendeley
38 Mendeley
Title
What the human sperm methylome tells us
Published in
Epigenomics, October 2017
DOI 10.2217/epi-2017-0049
Pubmed ID
Authors

Cristina Camprubí, Riccardo Aiese Cigliano, Albert Salas-Huetos, Nicolas Garrido, Joan Blanco

Abstract

To characterize the sperm methylome in semen samples from 19 donors with proven fertility. Bisulfite-converted sperm DNA was hybridized on the HumanMethylation450 Infinium BeadChip platform. CpG fluorescence intensities were extracted and converted to β-values. The sperm methylome is highly homogeneous and hypomethylated. Genes with hypomethylated promoters are ontologically associated to biological functions related to spermatogenesis and embryogenesis. Sex chromosomes are the most hypomethylated chromosomes, supporting data that indicated their essential role in spermatogenesis. A total of 94 genes are resistant to demethylation, being strong candidates for transgenerational inheritance. Spermatozoa carry a homogeneous methylation profile that is a footprint of past events (spermatogenesis), is designed to facilitate future events (embryogenesis) and has a possible influence in the adult life (transgenerational effects).

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 26%
Researcher 7 18%
Professor 3 8%
Student > Master 3 8%
Student > Bachelor 2 5%
Other 6 16%
Unknown 7 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 29%
Agricultural and Biological Sciences 10 26%
Medicine and Dentistry 4 11%
Nursing and Health Professions 1 3%
Environmental Science 1 3%
Other 2 5%
Unknown 9 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2018.
All research outputs
#6,207,619
of 22,558,632 outputs
Outputs from Epigenomics
#226
of 1,017 outputs
Outputs of similar age
#94,309
of 299,870 outputs
Outputs of similar age from Epigenomics
#9
of 24 outputs
Altmetric has tracked 22,558,632 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,017 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,870 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.